Benztropine

About these monographs

Category:

Neurological Antidote

 

Description:

Anticholinergic

Indications:

Acute dystonic reactions, drug-induced extrapyramidal disorders (except tardive dyskinesia)

Mechanism of Action:

Centrally acting antagonist of muscarinic acetylcholine and H1 histamine receptors. Also inhibits dopamine reuptake at nerve terminals.

Pharmacokinetics:

Route: IV/IM

Onset: 1-2 minutes

Peak Effects: <20 minutes

Duration: 1-2 hours

Contraindications:

Chronic dystonia, tardive dyskinesia, children aged < 3 years

Adverse Effects:

Dilated pupils, dry mouth, nausea and vomiting, tachycardia, toxic psychosis including confusion and visual hallucinations, urinary retention and/or dysuria, palpitations, headache

Precautions and Facts:

Sedative effects of other medications may be enhanced. Caution should be used in children aged

< 12 years. Other anticholinergic medication, alcoholism, narrow-angle glaucoma, IBD, GORD, IHD.

Presentation:

2 mg/mL ampoule

Dosages:

Age: Adult

Route: IV/IM

Initial Dose: 1-2 mg (single dose only)

Age: Adult

Route: IV/IM

Initial Dose: 20 mcg/kg (single dose only)

Cite as: Maria, S., Colbeck, M., & Caffey, M. (Eds.). (2020). Benztropine. In Paramedic & Emergency Pharmacology Guidelines (2nd ed.). Melbourne, Victoria: Pearson.

This book is for information purposes only and is designed as a general reference for paramedics, students and healthcare professionals  No responsibility will be taken for inaccuracies, omissions or errors  The authors do not accept liability to any person or organization for the information that may result in loss or damages incurred as a result of reliance upon the material in this guide While every effort has been made to ensure that the information in this text is up to date, accurate and in accordance with current clinical recommendations and practice, the dynamic nature of healthcare and pharmaceutical information requires any student or health professional to exercise independent clinical judgement when referring, using or providing information from this book

 

A body of evidence for the development of this guide has been collected by the authors to support the pharmacokinetics, indication, contraindications, adverse effects and dosage behind each medication  This body reflects information provided by Australia’s Therapeutic Goods Administration, Monthly Index of Medical Specialities, the United States’ Food and Drug Administration, and both peer-reviewed studies and clinical trials demonstrating the approved efficacy, usage and current understanding of each medication  Additionally, the Australian Resuscitation Council guidelines and each state ambulance service’s clinical practice guidelines in Australia and New Zealand were reviewed and applied in order to maximize the clinical application of this reference guide  Lastly, this guide’s information is not endorsed, nor does it reflect preferences by any particular pharmaceutical company or ambulance service as this reference was compiled only to the most current and universal information available from the above listed, publicly available resources

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