Haloperidol
Haloperidol
Other Names
•Haldol
•Peridol
•Dozic
•Serenance
Classification
•Antipsychotic
Action
•Unknown - a butyrophenone that probably exerts antipsychotic effects by blocking post synaptic dopamine receptors in the brain
Indications
•Psychotic disorders
•Chemical restraint of combative patients
Contraindications
•Hypersensitivity to the medication
•Patients with Parkinson’s, coma or CNS depression
Precautions
•Use cautiously in elderly and debilitated patients
•Patients with a history of seizure disorder, ECG abnormalities, severe CV disorders and glaucoma
•Patients on aniticoagulants, anticonvulsants, antiparkinsonians or lithium
Adverse Reactions
•Tachycardia, hypotension, hypertension
•Torsades de pointes, ECG changes
•Blurred vision
•Drowsiness, headache, insomnia, confusion
•Dry mouth, anorexia, nausea, vomiting
•Skin rash, urine retention
Interactions/Compatibility/Stability
•Anticholinergics, CNS depressants
•Lithium and alcohol use
Special Considerations
•Protect form light (slight yellowing of injection is common)
•Can be mixed in the same syringe as lorazepam or midazolam
Dosages
•Preparation: 5 mg/ml vial
•Adult: 2 - 5 mg IM/IV, every 5 - 10 minutes to a maximum of 30 mg
•Pediatric: N/A
Kinetics
Onset: < 10 minutes
Peak: 10-20 minutes
Duration: 4-6 hours
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