Other Names

Benadryl

Classification

Antihistamine

Action

H1 receptor blockers act by competitively blocking the receptor - mediated response of a target tissue (antagonizing all actions of histamine except those mediated solely by H2 receptors)

Indications

Treatment of severe allergic reaction

Prevention of allergic reaction during transfusion

Contraindications

Hypersensitivity to the medication

Precautions

May cause drowsiness

Adverse reactions

1. •Central nervous system depression
   

2. •Anticholinergic effects: dry mouth, blurred vision, difficulty in urination, tightness of chest, etc.
   

3. •Nausea and vomiting
   

4. •Changes in blood pressure and ECG changes
   

5. •Rarely hemolytic anemia and anaphylactic reaction
   

6. •Transitory irritation at injection site
   

Interactions/Compatibility/Stability

1. •Protect from light (darkens on exposure to light)
   

2. •Compatible with Dextrose, NS, Ringer’s Lactate solutions
   

Special Considerations

1. •Parenterally IV is the preferred route
   

2. •IM must be deep into large muscle mass
   

3. •Caution necessary in patients with hypertension, or cardiac distress
   

4. •May contain Sodium Bisulfate
   

dosages

Preparation:

1. •50 mg in 1 ml vial
   

2. •Infuse directly into IV line (over at least 1 minute) or in minibag
   

Adult: 1 mg/kg IV or IM (to a maximum of 50 mg)

Pediatric: 1 mg/kg IV or IM (to a maximum of 40 mg)

Kinetics

No documentation found

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